Frequency of different types of leukodystrophy in children using magnetic resonance spectroscopy.

Authors

  • iram_javed javed Children Hospital Faisalabad
  • DR AMINA REHAN REHAN Faisalabad Medical University & Affiliated hospitals
  • Dr Zonaira Shabbir
  • Dr Irfan Shabbir Faisalabad Medical University & Affiliated hospitals
  • Dr Tehmina kanwal Faisalabad Medical University & Affiliated hospitals
  • Dr Hina Rauf Faisalabad Medical University & Affiliated hospitals

DOI:

https://doi.org/10.66347/ppj.v50i2&3.716

Abstract

ABSTRACT

Objectives: To determine the frequency of different types of leukodystrophy in children using magnetic resonance spectroscopy.

Study design: Case series study.

Place and Duration of Study: Department of Radiology, Allied hospital, Faisalabad from July 2022 to December 2022.

Methodology: Total 130 patients of age 2 months to 15 years and either sex coming for MRI examination either for diagnosis of leukodystrophy were selected. 1H-MRS was performed for all patients for diagnosis of LD.

Results:In this study, frequency of different types of leukodystrophy in children using magnetic resonance spectroscopy were as follows; Krabbes disease in 15 (11.54%), Canavan’s disease in 23 (17.69%), Adreno LD in 48 (36.92%), Leigh disease in 30 (23.08%) and Metachromatic LD in 14 (10.77%).

Conclusion: This study concluded that MRS should be used in every patient with clinical leukodystrophies because it is cost effective as compared to other available tests.

Keywords: Leukodystrophies, Magnetic resonance spectroscopy, Krabb disease, Canavan disease.

Downloads

Published

2026-11-09

Issue

Vol. 50 No. 2&3 (2026)

Section

Articles