Early Recognition and Management of Nephrogenic Diabetes Insipidus in preterm newborn: A Vital Case Study

Authors

  • Nida Aslam AKHTAR SAEED MEDICAL AND DENTAL COLLEGE
  • Sommayya Aftab The children hospital and institute of child health sciences lahore
  • Sikander Hayat The children hospital and institute of child health sciences lahore

Keywords:

Hypernatremia  , dehydration, diabetes inspidus ,nephrogenic

Abstract

Abstract:

Diabetes insipidus (DI) is a rare condition in neonates, caused by arginine vasopressin deficiency in the hypothalamic-neurohypophysial system or a vasopressin receptor defect at the kidney level. Recognizing DI in neonates, especially extremely low birth weight (ELBW) and preterm infants, is challenging due to subtle symptoms. This case highlights the importance of considering DI in preterm, very low birth weight (VLBW) neonates presenting with polyuria, as early diagnosis and prompt management of water and electrolyte balance in these vulnerable infants is crucial for better outcomes. Our index case underscores the importance of considering rare causes of polyuria and persistent hypernatremia, emphasizing that timely diagnosis and management can significantly improve neurodevelopmental outcomes.

Keywords: Hypernatremia  , dehydration, diabetes inspidus ,nephrogenic

Author Biographies

Sommayya Aftab, The children hospital and institute of child health sciences lahore

Associate professor of paediatrics endocrinology and diabetes

Sikander Hayat, The children hospital and institute of child health sciences lahore

Associate professor of Neonatology

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Published

2025-12-11

Issue

Vol. 49 No. 3&4 (2025)

Section

Case Report