Frequency and Antimicrobial Sensitivity Pattern of Urinary Tract Infections in Late Onset Sepsis among Neonates at Children’s Hospital Lahore

Abstract

ABSTRACT

Objective: This study aimed to investigate the frequency and antimicrobial sensitivity patterns of urinary tract infections (UTIs) in neonates with late-onset sepsis in order to guide clinical decision-making and develop effective strategies for prevention and management of UTIs.

Study design: A cross-sectional study utilizing non-probability consecutive sampling and included neonates aged 7-28 days diagnosed with late onset sepsis.

Place and duration of study: Conducted at the Children's Hospital, Lahore, over a period of six months from September 2022 to March 2023.

Material and methods: Sample size of 100 neonates was estimated. Data including demographic information, urine samples, and antibiotic sensitivity patterns were collected and analyzed using SPSS v. 25.0. Chi-square test was applied for analysis and a p-value ≤ 0.05 was considered as significant.

Results: A mean age of 27.25 ± 4.45 days among neonates, with a male predominance of 77% was found. E. coli was the most common organism causing UTIs (64.7%), followed by Klebsiella (17.64%) and Staphylococci (11.76%). Pseudomonas was least commonly isolated (5.88%). Antibiotic sensitivity patterns varied among organisms, with Amikacin and Cefotaxime showing high sensitivity rates against E. coli. There was no significant difference in the frequency of different organisms between male and female neonates.

Conclusion: E. coli is the most frequently isolated organism in neonatal UTIs, with varying resistance and sensitivity patterns to different antibiotics. Understanding these patterns is crucial for guiding treatment decisions for the prevention and management of UTIs in neonates with LOS.

Keywords:

E. coli, Neonatal sepsis, UTIs, Antimicrobial pattern