The Efficacy of dexamethasone in treatment of meconium aspiration syndrome; a randomized clinical trial
Keywords:
Meconium aspiration syndrome, Steroids, Newborn infant, Developing countryAbstract
Objective: To determine efficacy of dexamethasone in treatment of meconium aspiration syndrome.
Study design: Randomized control trial.
Place and duration: Services hospital, Neonatal unit, Lahore. During time span of 1st January to 30th June 2021.
Material and methods
Total 100 neonates were randomly divided in two groups. Group A (n=50) was treated with dexamethasone (Cases) and Group B (n=50) served as control. Dexamethasone was given in dose of 0.2mg/kg, 12 hourly for 7 days after confirmation of diagnosis. Infants present in clinical trial were evaluated by ventilation duration (invasive and non-invasive), oxygen therapy and hospital stay.
Results: Our results showed 54% males and 46% females in group A and 60% males with 40% females in group B. Mean duration of invasive ventilation (days) in group A is 0.2 and group B is 2.8 and mean duration of non-invasive ventilation (days) in group A is 2.14 and group B is 2.42. Mean duration of hospital stay (days) in group A is 6.02 and B is 10.56.
Conclusion. In our study, we found shorter ventilation duration and hospital stay in group treated with steroid.
