Comparison of mean platelet volume in febrile neonates with or without neonatal sepsis.

Abstract

Objective:To compare mean platelet volume in febrile neonates with or with neonatal sepsis in emergency.

Study Design: Cross sectional study

Place and Duration of Study: This study was carriedout in the Paediatric department, Jinnah Hospital, Lahore. Its duration was six months from June 2021 to November 2021.

Material and Methods: Total 150 neonates with fever were included in the study. These neonates were evaluated for neonatal sepsis as peroperational definition. Their blood sample was collected in a 5cc disposable syringe to determine MPV level. All samples were sent to the laboratory of the hospital, reports were assessed and MPV level was noted. Statistical analysis was done using SPSSv25.0. Mean MPV was compared in children with or without neonatal sepsis by using independent sample t-test. Data were stratified for age, gender, gestational age and weight.

Results: Total 150 neonates with fever were enrolled in this study. 82 (54.7%) were male and 68 (45.3%) were female. The mean age of neonates was 36.6±20.7hours. The frequency of neonatal sepsis was 39(26.0%). The mean MPV level in neonatal sepsis was 8.61±1.21 fl and in neonates without sepsis was7.14±0.44 fl. Student’s t test was applied and difference between th two groups was found to be statistically significant (p<0.05).

Conclusion: Mean platelet volume was increased in neonates with neonatal sepsis as compared to neonates without sepsis. Such patients were at an increased risk of cardiovascular complications.