“Frequency of demyelinating form and axonal form in GBS amongst children in Intensive care unit-Tertiary care hospital”  : “Frequency of demyelinating form and axonal form in GBS amongst children in Intensive care unit-Tertiary care hospital”

Afsheen Raza; IRFAN NAEEM NAEEM; AFSHEEN BATOOL RAZA RAZA; AMNA KHALID KHALID

Authors

Afsheen Raza University of child health sciences and children hospital
IRFAN NAEEM Department of Paediatric Medicine, Children’s Hospital and the Institute of Child Health, Lahore, Pakistan.
AFSHEEN BATOOL RAZA Department of Paediatric Medicine, Children’s Hospital and the Institute of Child Health, Lahore, Pakistan.
AMNA KHALID

Abstract

ABSTRACT

AIMS AND OBJECTIVES:

To find out frequency of demyelinating form and axonal form in GBS amongst children in Intensive care unit of tertiary care hospital.
To compare mean duration of mechanical ventilation in children with Guillain-barré syndrome having demyelinating form and axonal forms on nerve conduction studies.

STUDY DESIGN: Cross sectional study

SETTING AND DURATION:

The research was conducted from March 15, 2020, to March 15, 2021, at the Medical Intensive Care Unit of The Children's Hospital and the Institute of Child Health in Lahore.

PATIENTS AND METHODS:

There were 52 patients admitted to the medical ICU who met the inclusion criteria. Every day, the patients were checked on. The nerve conduction studies were performed to define the types of GBS like Axonal and demyelinating. A log was kept of how long each patient required mechanical ventilation

RESULTS:

Children had a mean age of 9.85 years, ± 3.233 standard deviations. Nine (17.31%) of the children in the sample were female, while 43 (82.69%) were male. Thirty-seven (71.15%) of the children were diagnosed with the demyelinating form of Guillain-Barre, while 15 (28.85%) had the axonal form. Mechanical ventilation was required for a mean of 9.00 ± 3.51 days, with a minimum of 2 days and a maximum of 21 days.

CONCLUSION:

Children identified with the demyelinating type of Guillain-Barre syndrome were 37 (71.15%), while those diagnosed with the axonal form numbered 15 (28.85%), despite the latter group having higher mean ventilation. Long-term mechanical ventilation is associated with a poor prognosis for the underlying treatment, so it is important that in the future, greater attention be paid to these patients to prevent their respiratory failure. Since the length of ventilation is already known, prudent immunoglobulin use can also lower treatment costs.

KEY WORDS:

Guillain-barré syndrome, Axonal, demyelinating, mechanical ventilation.

“Frequency of demyelinating form and axonal form in GBS amongst children in Intensive care unit-Tertiary care hospital”