A Pakistani sample Population study of clinical associations with MR imaging patterns in Cerebral Palsy

Abstract

Objectives:

To describe and analyze various MRI imaging patterns in children with clinical diagnosis of Cerebral Palsy according to multiple peri/post natal factors, clinical subtypes of CP as well as motor/intellectual impairments.

Study Design:

Cross sectional analytical study

Place and Duration of study:

This study was conducted in Department of Developmental/Behavioral Pediatrics and Department of Pediatric Radiology, UCHS and The Children’s Hospital, Lahore over a duration of 3 months

Materials and Methods:

57 diagnosed patients of Cerebral Palsy were enrolled and assessed for various peri/post natal risk factors, types of CP and different impairments. MRI brain were performed and reported according to MRICS by Pediatric Radiologists. Descriptive analysis was performed using SPSS 24.

Results:

57.7% patients exhibited Predominant White Matter Injury (PWMI) while Predominant Gray Matter Injury (PGMI) was noted in 17.7% of patients. Bilateral spastic CP was the most commonly found subtype in this population found in 76.9% patients out of which 62.5% had PWMI on MRI brain followed by miscellaneous pattern. More than 50% of population suffered from birth asphyxia as prenatal risk factor and 32.7% patients suffered from neonatal infections as post natal risk factor with PWMI being the commonest MRICS pattern in both of these groups. Early motor and intellectual impairments were more common in this population with PWMI as commonest MRICS pattern.

Conclusion:

Standardized classification like MRICS of brain imaging findings can help in establishing the pathogenesis and various clinical manifestations of CP

Keywords:

Cerebral Palsy, MRICS, Birth asphyxia, motor function