COMPARISON OF MEAN DURATION OF E COMPARISON OF MEAN DURATION OF EARLY REMISSION OF NEPHROTIC SYNDROME IN CHILDREN TREATED WITH AND WITHOUT SUPPLEMENTARY ZINC

COMPARISON OF MEAN DURATION OF EARLY REMISSION OF NEPHROTIC SYNDROME IN CHILDREN TREATED WITH AND WITHOUT SUPPLEMENTARY ZINC

Abstract

ABSTRACT:

Objective:

To compare the mean duration of remission of nephrotic syndrome in children treated with and without supplementary zinc.

Study design:

Quasi experimental study design

Study Place and Duration:

The study was carried out at the Pediatric Department, Lahore General Hospital for a period of six months i.e. from April/2022 till September/2022.

Method:

50 children were given prednisolone at a dose of 2 mg/kg per day for 6 weeks and were then randomly divided into 2 groups of 25 children each. In group A, zinc sulphate was given orally at the dosage of 10 mg/day in < one years of age and 20mg/day in >1 years. Group B was not given any additional supplements. The patients were followed till the remission of the disease as calculated in days and was presented as mean.

Results:

The mean age of the children was 8.38±4.01, mean weight was 30 ±13.13, mean zinc levels in the serum at presentation were 95.6 ±13.48. Mean duration of early remission (in days) in group A was 13.36±5.85, whereas in group B was 16.96.58. Independent t-test was performed and it was found that the difference was statistically significant between the two groups in terms of duration of early remission as indicated by a p value of 0.049.

Conclusion:

Supplementation with zinc had less mean duration of early remission compared to the group without it.

Keywords: Nephrotic Syndrome, zinc, early remission