Frequency of Acute Kidney Injury in Neonate Present with Perinatal Asphyxia in a Tertiary Care Hospital, Karachi

Abstract

Background: Acute kidney injury (AKI) is a common problem in the neonatal intensive care units and is reported as an independently predicts morbidity and mortality.

Objective: To determine frequency of Acute kidney injury in neonate present with perinatal asphyxia.

Study Design: Descriptive cross sectional study

Place and Duration of Study: This study was conducted among 335 birth asphyxia neonates, born at Ruth Pfau CHK, in the duration of six months from January, 2020 to June, 2020.

Material and Method: Sample was collected by Utilizing Non-probability, consecutive sampling technique. Blood urea nitrogen, serum creatinine and serum electrolytes were evaluated by obtaining a 3 ml blood sample under aseptic measures, after 72 hours and before 96 hours of birth. Those with serum creatinine of > 2 standard deviation (SD) above of mean value for gestational age i.e. equal to 1.19 mg/dl10 were diagnosed as AKI.

Results: The mean age of the patients was 3.47 ±0.50 days. Gender distribution showed 219 (65.4%) males and 116 (34.6%) females. The frequency of acute kidney injury was found to be 176 (52.5%). A significant association of acute kidney injury was observed with gender (p-value 0.021) while age (p-value 0.512), gestational age (p-value 0.333), weight (p-value 0.510), and APGAR score (p-value 0.168) was found to be insignificant.

Conclusion: The frequency of acute kidney injury in neonates present with perinatal asphyxia was found to be considerably higher.

Keywords: Acute kidney injury, neonates, perinatal asphyxia